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PDF | The present study aims to evaluate the therapeutic properties of the medicinal plants (Vitex negundo, Aegle marmelos and Boswellia serrata) for their . Abstract To evaluate the anti-inflammatory activity of Vitex negundo (VN) leaf extract and its mechanism of action in experimental animals. Carrageenin induced. Abstract. The present study was undertaken to assess the anti-inflammatory effect of ethanolic extract of Vitex negundo roots in rats.

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Volume of the injected paw was measured plethysmographically immediately after the injection and then again at hourly intervals up to 4h. Cycloxygenase 1 and 2. Vitex negundo VN Linn verbenaceaea large aromatic shrub with typical five foliolate leave pattern, found throughout the greater part of India at warmer zones and ascending to an altitude of m in nwgundo, Western Himalayas.

Whereas, to study the effect of test drug on oxidative stress by MDA level estimation. Acute Toxicity Study Albino mice of either sex, weighing gm were used to determine the lethal dose. Total yield of extract was zctivity The ethno medical use of V. Natural phenolic in the prevention of UV-induced inflammatoyr damage: It is well established that oxytocin induced uterine contractions are partly mediated through prostaglandins Rall, Medicinal uses and biological activities of Vitex negundo.

The difference in wet and dry weights of granuloma from control group to that of treated group indicates the anti-inflammatory activity. During the aerobic incubation of tissue homogenates, infllammatory are formed which on reaction with thiobarbituric acid produced a pink colour. These findings are in agreement to findings of Dharmasiri et al. Critical analysis of the studies done on indigenous anti-inflammatory and anti-arthritic drug during post independence era.

Similarly, fresh leaves of VN have been suggested to possess anti-inflammatory and pain suppressing activities possibly mediated via PG synthesis inhibition, antihistamine, membrane stabilising and antioxidant activities Dharmasiri et al.

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Free Radical scavenging activity of Syzygium cumuni and Ficus bengalensis plants used in Ayurveda for Diaibetus mellitus. Negunso tubes were then centrifuged at rpm for 10 min and cooled. Kundnani College of Pharmacy. Ethanolic leaf extract of VN in the form of suspension was fed orally in a volume of 10 mL kg -1 wt.

All the respective grouped animals were injected with carrageenan 0. The reactive inclammatory species are also known to activate matrix metalloproteinase e.

The reduction in the volume displacement of hind foot in comparison to control was taken as anti-inflammatory infla,matory.

Antioxidant and Antiinflammatory Activity of Vitex negundo

The animals from cotton granuloma test were used in four groups with ten animals in each group. Five groups of 6 mice each were administered with aqueous extract at 1. In cotton pellet granuloma test VN extract in graded dosesand mg kg Therefore, reduction of oxidative stress by anti-lipoperoxidative activity might possibly be the mechanism of anti-inflammatory action of VN in model of sub-acute inflammation.

Effect of Vitex negundo extract on oxidative stress by plasma estimation of malondialdehyde MDA. The finding of present study strengthens the finding of Dharmasiri et al.

Antioxidant and Antiinflammatory Activity of Vitex negundo.

On the contrary, Sahni et al. Ascorbic acid protects lipid in human plasma and low density lipoprotein against oxidative damage. Indian Council of Medical Research India 2: The plant was collected from local area of Sevagram in the month of June, Protective activity of some indigenous medicinal plants on gastric ulceration in albino rats.

The action started at half an hour except with mg kg -1 dose of the test drug, where it was delayed to 1 h. The difference between 1 h and subsequent hours reading was taken as actual edema volume [ 12 ].


Flavonoids as anti-oxidants evaluated by in vitro and in situ liver chemiluminescence. This is because of the adverse effects associated with synthetic drugs. Anti-inflammatory effect of Vitex negundo extract in albino rats By carrageenin induced rat hind paw edema method. The extract also exhibited a strong free radical scavenging activity by 1,1-diphenylpicrylhydrazyl method and caused a significant reduction in the formation of thiobarbituric acid reacting substances when evaluated for its lipid peroxidation inhibitory activity.

Absorbance of the resulting pink chromogen was recorded at nm. Select your language of interest to view the total content in your interested language.

Springer Science and Business Media, Diclofenac sodium was obtained from Mac Labs, Mumbai as a gift sample. Proceedings of the international workshop, Lucknow: A mark nefundo put on the leg at the malleolus to facilitate uniform dipping at subsequent readings. Non-steroidal anti-inflammatory drugs; p.

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VN extract was administered orally in graded dosesand mg nehundo -1 as single dose therapy and twice daily for 7 day in respective inflammatory experimental models. Group V received phenylbutazone mg kg -1 orally and Ibuprofen mg kg -1 B. Carrageenin induced hind paw nsgundo and cotton pellet granuloma test in albino rats were employed to study the inflxmmatory activity of Vitex negundo VN leaf extract.

Patel Road, Bilimora, D: Lipid peroxidation is responsible for damaging cell membranes thereby further intensifying inflammatory damage. Antioxidant functions of carotenoids. J Agri Food Chem Gum acacia, phosphoric acid, potassium ferricyanide, ferric chloride were of LR grade and obtained from local suppliers.

Studies on analgesic and anti-inflammatory activities of Vitex negundo Linn. Please review our privacy policy.